Substrate for several CYPs, including 3A4. Potent mechanism-based CYP 3A4 inhibitor.

(To be edited, initial data ST OCT 04) Benzodiazepine dervative with calcium antagonistic action, metabolized to desmetyl and desacetyl diltiazem. Substrate of CYPs 2C8,2C9, 2D6, 3A4, 3A5, 3A7. Inhibitor of 2C8, 2C9, 2D6. Potent mechanism-based inhibitor of 3A4. Andersson, patient report (n=3): tolerated. James and Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use with care. South African list: use with care. French list: authorized. Kauppinen and Mustajoki. Prognosis of acute porphyria: Occurrence of acute attacks, precipitating factors,and assocciated diseases. Medicine 1992; 71, 1-13 : tolerated (n=1).

Uneventful use reported in 1 patient with acute porphyria.