One component (Miconazole) is possibly a CYP-inducer as well as inhibitor of several CYPs. Warned against in two references. Hydrocortisone: Glucocorticoid. Substrate for CYPs 3A4, 3A7, 11 B2. Inducer and inhibitor of CYP 3A4. Several references stating non-porphyrinogenicity. The combination is reported to be tolerated in 2 patients; in 1 patient it is suspected to have caused porphyric symptoms.

(To be edited, initial data ST OCT 04) Antimycotic combined with mild glucocorticoid used in mycoses with inflammatory engagement. No data on the extent of absorbtion but should not be more pronounced than for miconzole alone, i.e. insignificant. Miconazole: broadspectrum imidazole antimycotic creme for dermatological use in thin application. Only slightly absorbed. Inhibitor of CYPs 11B1, 19 (aromatase), 1A2, 2A6, 2B6 (potent), c19 (potent), 2D6 (potent), 3A4 (potent) and 51. Hydrocortisone Weak glucocorticoid. Hydrocortisone: South African list: use. Kalman, Bonkovsky: believed to be safe The Merck Index: safe. Moore MR, Hift RJ: Drugs in acute porphyria. Cell Mol Biol 43:89, 1997: safe. Tschudy and Lamon: : safe. Miconazole: South African list: avoid. French list: interdit. Thunell, patient report (n=1): tolerated. C.Andersson; patient reports: tolerated (n=2; possible adverse reaction (n=1))

Uneventful use reported in 1 patient with acute porphyria.