The glucocorticoid and ASA components are stated in several references not to be porphyrinogenic. Probably only insignificant systemic exposure.

(To be edited, initial data ST OCT 04) Strong glucocorticoid 0.5 mg/g in combination with acetylsalicylic acid. Ointment used in steroide sensitive dermatoses. Glucocorticoid : South African list: use. Kalman, Bonkovsky: believed to be safe. The Merck Manual: safe. Tschudy DP, Lamon JM: Porphyrin metabolism and the Porphyrias in Bondy BK, Rosenberg LE (eds): Duncan’s Diseases of Metabolism, Philadelphia, WB Saunders 1980, p 939: safe. Moore MR, Hift RJ: Drugs in acute porphyria. Cell Mol Biol 43:89, 1997: safe. Acetylsalicylic acid: South African list: safe. Kalman, Bonkovsky: safe. Michael Moore’s list: safe. The Merck Manual: safe . Eales L: Porphyria and the dangerous lifethreatening drugs, S Afr Med 56:914, 1979: safe.

Uneventful use reported in 1 patient with acute porphyria.