Acute Porphyria Drug Database

G02AD02 - Dinoprostone
Propably not porphyrinogenic
PNP

Rationale
Endogenous prostaglandin. Low dose. Probably insignificant hepatic CYP metabolic load.
Chemical description
(To be edited, initial data ST OCT 04) (DINOPROSTONE) Endogenous prostaglandin F2 alpha in vaginal gel (0.5- 2 mg /dose) used for cervix maturation and induction of labour. Short half life. Inactivated on passing the lungs. Metabolized by beta oxidation. Substrate for CYP 4F8. Inhibitor of CYPs 2B6 and 2C9.

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