Acute Porphyria Drug Database

H02AB04 - Methylprednisolone
Possibly porphyrinogenic
PSP

Rationale
Glucocorticoid. Substrate, inhibitor and activator / stimulator of CYP 3A4. Several references consider it safe.
Chemical description
(To be edited, initial data ST OCT 04) Glucocorticoid for intramuscular administration or local injection. Metabolized by CYP 3A4. Glucocorticoids: South African list: use. French list: authorized. Kalman, Bonkowsky: probably safe Michael Moore's list: safe. The Merck Manual: safe. Tschudy DP, Lamon JM: Porphyrin metabolism and the Porphyrias in Bondy BK, Rosenberg LE (eds): Duncan’s Diseases of Metabolism, Philadelphia, WB Saunders. 1980,p 939. :safe. Moore MR, Hift RJ: Drugs in acute porphyria. Cell Mol Biol 43:89, 1997:safe

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