In general, vaccines are regarded safe since such substance is not suspected to give an up-regulation of the heme biosynthesis as a direct effect. However, some vaccines can cause a reaction with high fever persisting over days as a side effect. It is possible that this side effect can trigger an acute porphyric attack in the same way as infections are known to. Vigilance is therefore motivated when administrating a vaccine known to cause reactions with fever.

Fever is reported as a very common side effect the combined measles, mumps and rubella vaccine, and it is possible that this side effect can trigger an acute porphyric attack in the same way as infections are known to.

Based on the pharmacokinetics of the measles, combinations with mumps and rubella vaccine, there are no conceivable porphyrinogenic effects.

Live, attenuated measles, mumps and rubella viruses.

The measles, combinations with mumps and rubella vaccine is indicated for simultaneous vaccination against measles, mumps, and rubella in individuals from 12 months of age. It is administered by intramuscular injection.

The measles, combinations with mumps and rubella vaccine is not metabolized by the Cytochrome P450 system.