Acute Porphyria Drug Database

M01CC01 - Penicillamine
Not porphyrinogenic
NP

Rationale
Non-aromatic valine derivative. Non-CYP dependent metabolism. Did not induce ALAS1 in rat. One reference: use.
Chemical description
(To be edited, initial data ST OCT 04) Antirheumatic mercaptovaline derivative, used in serious cases of RA where conventional treatment is without effect. Metabolized to disulfide and cystein disulfide, as well as mercaptovaline and methylpenicillinamine. Inhibitor of CYP 3A4. South African list: use.

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