Acute Porphyria Drug Database

N05AX08 - Risperidone
Probably porphyrinogenic
PRP

Rationale
Substrate of CYPs 2D6 (major enzyme) and 3A4. Inhibitor of CYPs 2D6, 3A4. Observation of one possible attack.
Chemical description
(To be edited, initial data ST OCT 04) Antipsychotic benzisoxasol derivative used in various forms of schizophrenia. Metabolized by CYPs. Thunell; Clinical observation (n=2): tolerated. Badminton: One possible observation of precipitation of an acute attack. See Holoryd S et al. Psychotropic drugs in acute…(one case) (PMID: 10511069).

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