R01AD08 - Fluticasone |
Not porphyrinogenic |
NP |
Rationale
Probably insignificant systemic exposure. Several references stating non-porphyrinogenic metabolism of glucocorticoids.
Chemical description
(To be edited, initial data ST OCT 04) Antiasthmatic antiinflammatory glucocorticoide, administered as inhalation powder (50 - 250 µg/dose). Systemic exposure about 16% of the taken dose. Rapidly metabolized by CYP 3A4 (within 3-4 hours). EPI-list: safe French list: authorized South African list: use Kalman, Bonkowski: safe The Merck Manual: safe Tschudy DP, Lamon JM: Porphyrin metabolism and the porphyrias, in Bondy PK, Rosenberg LE (eds.): Duncan's Diseases of Metabolism. Philadelphia, WB Saunders, 1980, p939: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe
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