Acute Porphyria Drug Database

S01EC03 - Dorzolamide
Propably not porphyrinogenic
PNP

Rationale
sulfonamide mainly distributed to erythrocytes. Probably insignificant systemic load. CYP metabolised, long duration of the final elimination phase.
Chemical description
sulfonamide used in eyedrops (20 mg/mL) to reduce the intraocular pressure in glaucoma. Converted to N-desethyl dorzolamide which binds to carbanhydrase. Reaches circulation in topical application but due to effective bindnding to erytrocyte carboanhydrases the plasma levels are very low. Metabolized by CYPs 3A3/4 and 2C9/10. A final elimination phase with a half time of four months takes place after termination of treatment.

Similar drugs
Explore alternative drugs in similar therapeutic classes S01E / S01EC or go back.

 
© NAPOS 2024
An unhandled error has occurred. Reload 🗙