Monograph
C03DB01 - Amiloride |
Not porphyrinogenic |
NP |
Rationale
CAVE: currently under revision. Not metabolised in the liver. Several references refer to amiloride as safe in acute porphyrias. Occasional clinical experience of tolerance. Amiloride seems to be the drug of choice among potassium saving diuretics.
Chemical description
Pyrazincarbonyl guanidine derivative.
Therapeutic characteristics
Potassium saving diuretic.
Metabolism and pharmacokinetics
Apparantly not metabolized; excreted in unchanged form in urine.
Preclinical data
No data pointing to CYP-induction.
Personal communication
Thunell, patient report (n=2): tolerated. Andersson, patient report (n=2): tolerated.
IPNet drug reports
Uneventful use reported in 9 patients with acute porphyria.
Similar drugs
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