Monograph
C03DB01 - Amiloride |
Not porphyrinogenic |
NP |
Rationale
CAVE: currently under revision. Not metabolised in the liver. Several references refer to amiloride as safe in acute porphyrias. Occasional clinical experience of tolerance. Amiloride seems to be the drug of choice among potassium saving diuretics.
Chemical description
Pyrazincarbonyl guanidine derivative.
Therapeutic characteristics
Potassium saving diuretic.
Metabolism and pharmacokinetics
Apparantly not metabolized; excreted in unchanged form in urine.
Preclinical data
No data pointing to CYP-induction.
Personal communication
Thunell, patient report (n=2): tolerated. Andersson, patient report (n=2): tolerated.
IPNet drug reports
Uneventful use reported in 9 patients with acute porphyria.
Similar drugs
Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Amilamont · Amiloride · Amoride 
Amiloride · Modamide 
Modamide
© NAPOS 2025