Monograph
C08DA01 - Verapamil |
Probably porphyrinogenic |
PRP |
Rationale
Substrate of several CYPs, including 3A4. Potent CYP 3A4 inhibitor. Autoactivator of CYP 2B6, probably quantitatively insignificant. Some clinical experience of tolerance. Two references state (probable) non-porphyrinogenicity.
Chemical description
Verapamil / norverapamil: Phenylalkylamine derivatives with calcium antagonistic action. Metabolized by CYPs 2C8, 3A4, 3A5, 2C9, 2E1, 1A2, 2B6, 2C19. Inhibitor of CYPs 2C8, 1A2, 2C9, 3A4 (potent) 2D6, 2C19. Autoactivator of CYP 2B6. MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use with care. Thunell, patient report (n=2): tolerated. Andersson, patient reports: tolerated (n=4). South African list: use with care French list: use. Kauppinen and Mustajoki. Prognosis of acute porphyria: Occurrence of acute attacks, precipitating factors,and assocciated diseases. Medicine 1992; 71, 1-13 : tolerated (n=1).
IPNet drug reports
Uneventful use reported in 4 patients with acute porphyria.
Similar drugs
Tradenames
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Isoptin · Verapamil 
Fibrocard · Isoptine · Lodixal 
Manidon 
Isoptin · Verapamil 
Cordamil · Isoptin · Verapamil 
Cordilox · Cordilox MR · Ethimil MR · Half Securon SR · Ranvera MR · Securon · Securon IV · Securon SR · Univer · Vera-Til SR · Verapamil · Verapress MR · Vertab SR 240 · Zolvera 
Isoptin · Isoptine · Veraloc · Veramacor · Verapamil · Verapamilhydrochlorid 
Isoptin · Veramacor · Verapamil 
Isoptin · Staveran 
Isoptin 
Isoptin · Veraloc 
Isoptin · Veramacor · Verpamil 
Isoptin 
Isocor · Verapamil
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