Monograph

C09AA03 - Lisinopril

Not porphyrinogenic

Rationale

Not metabolised. Some clinical experience as well as two references point to non-porphyrinogenicity. Risk for gastrointestinal adverse events in the form of diarrhoea and vomiting motivates vigilance against insufficient intake of food, especially of carbohydrate.

Chemical description

ACE-inhibitor. Excreted in unchanged form in urine. Thunell, patient reports (n=4): tolerated. Andersson, patient reports (n=7): tolerated. Used in Swedish porphyria ward. French list: safe. South African list: use with care.

Therapeutic characteristics

Common side effects that can be potentially porphyrinogenic through reduction in carbohydrate intake and that also can be confused with an acute porphyria attack are diarrhoea and vomiting.

IPNet drug reports

Uneventful use reported in 26 patients with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes C09A / C09AA or go back.

Tradenames

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