Monograph
C09AA04 - Perindopril |
Propably not porphyrinogenic |
PNP |
Rationale
Clinical experience and pharmacokinetic data points to non-porphyrinogenicity.
Risk for gastrointestinal adverse events in the form of nausea, vomiting, abdominal pain, dyspepsia, diarrhoea and obstipation motivates vigilance against insufficient intake of food, especially of carbohydrate.
Chemical description
(2S,3aS,7aS)-1-{N-[(S)-1-Ethoxycarbonylbutyl]-l-alanyl}perhydroindole-2-carboxylic acid. M= 368.5
Therapeutic characteristics
Perindopril is an angiotensin-converting enzyme (ACE) inhibitor used in hypertension, heart failure, and myocardial infarction.
Common side effects that can be potentially porphyrinogenic through reduction in carbohydrate intake and that also can be confused with an acute porphyria attack are nausea, vomiting, abdominal pain, dyspepsia, diarrhoea and obstipation.
Metabolism and pharmacokinetics
The prodrug perindopril is extensively metabolised, mainly in the liver, to the active perindoprilat and inactive metabolites including glucuronides. Perindoprilat and its metabolites are excreted principally in urine. The ACE inhibitors do not appear to undergo interactions via cytochrome P450 isoenzymes.
IPNet drug reports
Uneventful use reported in 23 patients with acute porphyria.
References
| # |
Citation details |
PMID |
|---|
| * | Drug interaction databases |
| 1. |
Martindale - The complete drug reference. Stockleys drug interactions.
|
|
Similar drugs
Tradenames and packages
From some sources, we get a list of packages (United Kingdom, Ireland, Estonia).
Other sources contain more or less "clean" versions of the trade name (Denmark, Finland, Iceland, Lithuania, Norway).
What you see here is the raw data we get from each country, so there will appear to be duplicates. The bold names
are the searchable terms. The gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Netherlands
Belgium
United Kingdom
Denmark
Norway
Poland
Luxembourg
Iceland
Finland
Latvia
Serbia
