Monograph

C09BA03 - Lisinopril and Diuretics

Not porphyrinogenic

Rationale

The two pharmacologically active substances lisinopril and hydrochlorothiazide, are not metabolised.

Chemical description

Lisinopril: ACE-inhibitor. Exceted in urine in unchanged form. Hydrochlorthiazide: Thiazide diuretic, sulfonamide congener Eliminated in urine in unchanged form. Probably no CYP-affinity. Lisinopril: Andersson, patient report (n=7): tolerated. South African list: use with care. French list: authorized. Hydrochlorthiazide: South African list: use. French list: authorized. Australian list: unsafe associated with attacks. Thunell, patient report (n=1): tolerated. Andersson, patient reports (n=10): tolerated. Martindale: Hydrochlorthiazide has been associated with acute attacks of porphyria and is considred unsafe in porphyric patients. EPI-list: sulfonamides on the unsafe list.

IPNet drug reports

Uneventful use reported in 1 patient with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes C09B / C09BA or go back.

Tradenames

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Lisinopril / Hydrochloorthiazide

Co-Lisinopril · Zestoretic

Doneka Plus · Iricil Plus · Lisinopril / Hidroclorotiazida · Lisinopril-Hidroclorotiazida · Lisinopril/ Hidroclorotiazida · Prinivil Plus · Tensikey Complex · Zestoretic