Limitations: This safety classification applies only to preparations containing a combination of the two drugs losartan and hydrochlorotiazide. The same ATC-code (C09D A01) can in some countries be used for different combinations of losartan and other drugs, which in theory may be porphyrinogenic. Please refer to the classification and monograph of each individual substance. If the combination contains a substance which is not classified (NC) or has been classified as porphyrinogenic (PSP, PRP or P), the safety classification of such a combination as PNP is no longer valid. Combination products which contains the two substances losartan (ATC code: C09C A01) and hydrochlorotiazide (ATC code: C03A A03) are safety classified as Probably not porphyrinogenic (PNP), as both of them are safety classified as Probably not porphyrinogenic (PNP) separately. For more details please refer to the monographs of the two substances.

Uneventful use reported in 1 patient with acute porphyria.