Monograph

C09DA03 - Valsartan and Diuretics

Propably not porphyrinogenic

Rationale

Valsartan: Not metabolised. Hydrochlorothiazide: South African list: use. French list: autorisÃ©. Australian list: unsafe associated with attacks. Thunell, patient report (n=1): tolerated. Andersson, patient reports (n=10): tolerated. Martindale: Hydrochlorothiazide has been associated with acute attacks of porphyria and is unsafe in porphyric patients. EPI-list: sulfonamides on the unsafe list.

Chemical description

Valsartan: Angiotensin II receptor antagonist. Bioavailability 23 %. Eliminated in unchanged form. Less potent inhibitor of CYP 2C9. Hydrochlortiazide: Tiazide diuretic, sulfonamide congener. Eliminated in urine in unchanged form. Probably no CYP-affinity. Hydrochlortiazide: South African list: use. French list: autorisÃ©. Australian list: unsafe associated with attacks. Thunell, patient report (n=1): tolerated. Andersson, patient reports (n=10): tolerated. Martindale: Hydrochlortiazide has been associated with acute attacks of porphyria and is considred unsafe in porphyric patients. EPI-list: sulfonamides are on the unsafe list.

IPNet drug reports

Uneventful use reported in 3 patients with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes C09D / C09DA or go back.

Tradenames and packages

From some sources, we get a list of packages (United Kingdom, Ireland, Estonia). Other sources contain more or less "clean" versions of the trade name (Denmark, Finland, Iceland, Lithuania, Norway). What you see here is the raw data we get from each country, so there will appear to be duplicates. The bold names are the searchable terms. The gray names that follow are all mapped to the bolded term.

Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.

Netherlands

Co-Diovan · Co-Diovan 160/12,5, 160 mg/12,5 mg filmomhulde tabletten · Co-Diovan 160/25, 160 mg/25 mg filmomhulde tabletten · Co-Diovan 320/12,5, 320 mg/12,5 mg filmomhulde tabletten · Co-Diovan 320/25, 320 mg/25 mg filmomhulde tabletten · Co-Diovan 80/12,5, 80 mg/12,5 mg filmomhulde tabletten · Exart Plus · Exart Plus 160/12,5 mg, filmomhulde tabletten · Exart Plus 160/25 mg, filmomhulde tabletten · Exart Plus 80/12,5 mg, filmomhulde tabletten · Valsartan / Hydrochlorothiazide · Valsartan/Hydrochloorthiazide 160 mg/12,5 mg PCH, filmomhulde tabletten · Valsartan/Hydrochloorthiazide 160 mg/25 mg PCH, filmomhulde tabletten · Valsartan/Hydrochloorthiazide 80 mg/12,5 mg PCH, filmomhulde tabletten · Valsartan/Hydrochloorthiazide Krka 160 mg/12,5 mg, filmomhulde tabletten · Valsartan/Hydrochloorthiazide Krka 160 mg/25 mg, filmomhulde tabletten · Valsartan/Hydrochloorthiazide Krka 320 mg/12,5 mg, filmomhulde tabletten · Valsartan/Hydrochloorthiazide Krka 320 mg/25 mg, filmomhulde tabletten · Valsartan/Hydrochloorthiazide Krka 80 mg/12,5 mg, filmomhulde tabletten · Valsartan/hydrochloorthiazide Liconsa 160 mg/25 mg, filmomhulde tablet · Valsartan/hydrochloorthiazide Liconsa 80 mg/12,5 mg, filmomhulde tablet · Valsartan/Hydrochloorthiazide Mylan 160 mg/12,5 mg, filmomhulde tabletten · Valsartan/Hydrochloorthiazide Mylan 160 mg/25 mg, filmomhulde tabletten · Valsartan/Hydrochloorthiazide Mylan 320 mg/12,5 mg, filmomhulde tabletten · Valsartan/Hydrochloorthiazide Mylan 320 mg/25 mg, filmomhulde tabletten · Valsartan/Hydrochloorthiazide Mylan 80 mg/12,5 mg, filmomhulde tabletten · Valsartan/Hydrochloorthiazide Sandoz 160/12,5 mg, filmomhulde tabletten · Valsartan/Hydrochloorthiazide Sandoz 160/25 mg, filmomhulde tabletten · Valsartan/Hydrochloorthiazide Sandoz 320/12,5 mg, filmomhulde tabletten · Valsartan/Hydrochloorthiazide Sandoz 320/25 mg, filmomhulde tabletten · Valsartan/Hydrochloorthiazide Sandoz 80/12,5 mg, filmomhulde tabletten · Valsartan/Hydrochloorthiazide Viatris 160 mg/12,5 mg, filmomhulde tabletten · Valsartan/Hydrochloorthiazide Viatris 160 mg/25 mg, filmomhulde tabletten · Valsartan/Hydrochloorthiazide Viatris 320 mg/12,5 mg, filmomhulde tabletten · Valsartan/Hydrochloorthiazide Viatris 320 mg/25 mg, filmomhulde tabletten · Valsartan/Hydrochloorthiazide Viatris 80 mg/12,5 mg, filmomhulde tabletten · Valsartan/HCT · Valsartan/HCT Jubilant 160 mg/25 mg, filmomhulde tabletten · Valsartan/HCT Jubilant 80 mg/12,5 mg, filmomhulde tabletten

Belgium

Co-Diovane · Co-Diovane 160 mg - 12.5 mg compr. pellic. · Co-Diovane 160 mg - 25 mg compr. pellic. · Co-Diovane 80 mg - 12.5 mg compr. pellic. · Co-Valsartan · Co-Valsartan EG 160 mg - 12.5 mg compr. pellic. · Co-Valsartan EG 160 mg - 25 mg compr. pellic. · Co-Valsartan EG 80 mg - 12.5 mg compr. pellic. · Co-Valsartan Sandoz 160 mg - 12.5 mg compr. pellic. · Co-Valsartan Sandoz 160 mg - 25 mg compr. pellic. · Co-Valsartan Sandoz 80 mg - 12.5 mg compr. pellic. · Valsartan / Hydrochlorothiazide · Valsartan/Hydrochlorothiazide KRKA 160 mg - 12.5 mg compr. pellic. · Valsartan/Hydrochlorothiazide KRKA 160 mg - 25 mg compr. pellic. · Valsartan/Hydrochlorothiazide KRKA 320 mg - 12.5 mg compr. pellic. · Valsartan/Hydrochlorothiazide KRKA 320 mg - 25 mg compr. pellic. · Valsartan/Hydrochlorothiazide KRKA 80 mg - 12.5 mg compr. pellic.

United Kingdom

Co-Diovan · Co-Diovan 160mg/12.5mg tablets · Co-Diovan 160mg/25mg tablets · Co-Diovan 80mg/12.5mg tablets · Valsartan / Hydrochlorothiazide · Valsartan 160mg / Hydrochlorothiazide 12.5mg tablets · Valsartan 160mg / Hydrochlorothiazide 25mg tablets · Valsartan 80mg / Hydrochlorothiazide 12.5mg tablets

Denmark

Tevavaltan Comp · Tevavaltan comp. · Valsartan / Hydrochlorothiazide · Valsartan/Hydrochlorothiazide "Krka" · Valsartan/Hydrochlorthiazid "Teva" · Valsartan/hydroklortiazid "Jubilant" · Valsartore Comp · Valtension Comp · Valtension comp. · Valteva Comp · Valteva comp.

Norway

Diovan Comp · Valsartan / Hydrochlorothiazide · Valsartan/Hydrochlorothiazide Krka

Poland

AuroValsart HCT · Axudan HCT · Co-Bespres · Co-Diovan · Co-Dipper · Co-Valsacor · Tensart HCT · Vabinxo · Valsartan / Hydrochlorothiazide · Valsartan + hydrochlorothiazide Krka · Valsartan HCT Fair-Med · Valtap HCT · Vanatex HCT

Luxembourg

Co-Diovane · Co-Valsartan · Co-Valsartan EG 160mg/12,5mg · Co-Valsartan EG 160mg/25mg · Co-Valsartan EG 80/12,5mg · Valsartan Comp · Valsartan-ratiopharm comp. 320mg/12,5mg · VALSARTAN-RATIOPHARM COMP.-160/12,5 · VALSARTAN-RATIOPHARM COMP.-160/25 · Valsartan-ratiopharm comp.-320mg/25mg · VALSARTAN-RATIOPHARM COMP.-80/12,5

Iceland

Almertan · Malartan HCT · Valpress Comp · Valsartan / Hydrochlorothiazide · Valsartan/Hydrochlorothiazide Krka · Valsartan/Hydroklortiazid Jubilant

Finland

Diovan Comp · Valomindo · Valsartan / Hydrochlorothiazide · Valsartan/Hydrochlorothiazide Krka · Valsartan/Hydrochlorothiazide Sandoz · Valsartan/Hydroklortiazid Actavis · Valsartore Comp

Latvia

Co-Diovan · Vabinxo · Valsacombi · Valsol plus

Serbia

Co-Diovan · Co-Diovan® · Valomindo · Valomindo® · Valsacombi · Valsacombi®

Acute Porphyria Drug Database

Monograph