Monograph
C10AA03 - Pravastatin |
Propably not porphyrinogenic |
PNP |
Rationale
Pravastatin is not a substrate of CYP enzymes.
Chemical description
HMG-CoA reductase inhibitor.
Therapeutic characteristics
Pravastatin is indicated for the treatment of hypercholesterolemia and cardiovascular prevention.
Less common side effects are dyspepsia, abdominal pain, nausea, vomiting, constipation and diarrhoea.
Metabolism and pharmacokinetics
Pravastatin is not a substrate of CYP3A enzymes (Flockhart 2007) and is metabolized by non-P450-dependent pathways (Corsini 1999, Masubuchi 2007) and is also excreted mainly unchanged (Neuvonen 2008). 50 % is bound to plasma proteins and the elimination half-life is 1.5-2 hours.
In vitro studies have shown that pravastatin has no effect on either CYP3A or CYP2B6 (Dickins 2004, Kocarek 2002).
Personal communication
Thunell, patient report (n=1): tolerated.
IPNet drug reports
Uneventful use reported in 4 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | New insights into the pharmacodynamic and pharmacokinetic properties of statins.
Corsini A, Bellosta S, et al. Pharmacol Ther. 1999 Dec;84(3):413-28. |
10665838 |
| 2. | Induction of cytochromes P450.
Dickins M. Curr Top Med Chem. 2004;4(16):1745-66. |
15579106 |
| 3. | Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes.
Kocarek TA, Dahn MSm, et al. Drug Metab Dispos. 2002 Dec;30(12):1400-5. |
12433810 |
| 4. | Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs.
Masubuchi Y, Horie T. Crit Rev Toxicol. 2007 Jun;37(5):389-412. |
17612953 |
| 5. | Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin.
Neuvonen PJ, Backman JT, Niemi M. Clin Pharmacokinet. 2008;47(7):463-74. |
18563955 |
| * | Drug interaction databases | |
| 6. | Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007).
Flockhart DA. |
|
Tradenames
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In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
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Pravasor · Pravastatine · Pravastatinenatrium 
Prareduct · Pravasor · Pravastatin · Pravastatine 
Bristacol · Liplat · Minuscol · Prareduct · Pravastatina · Pravastatina Codramol10 · Pritadol 
Aplactin · Langiprav · Prasterol · Pravaselect · Pravastatina · Setac · Vasticor 
Lipostat · Pravastatin 
Pravastatin · Pravastatinnatrium 
Pravastatin 
Pravator 
Prareduct · Pravasor · Pravastatine 
Pravastatin 
PravaCor
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