Monograph
D01AC01 - Clotrimazole |
Propably not porphyrinogenic |
PNP |
Rationale
Potent inducer of CYP 3A4. Inducer of CYPs 2C8, 2C9. No significant systemic exposure in dermatological use.
Chemical description
Broadspectrum imidazole antimycotic creme 1% or cutaneous solution 1% for dermatological use in thin application Inhibitor of CYPs 11B1, 17, 19 (Aromatase), 1A2, 2A6, 2C19 (potent), 2C8 (potent), 2D6. Potent CYP- inducer. No systemic effects even in long term treatment.
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
Similar drugs
Tradenames
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Canesten · Clotrimazol 
Canestene · Canestene Intim 
Canespie Clotrimazol · Canesten · Clotrimazol · Clotrimazol Canesmed 
Canesten · Clotrimazol 
. · Abtrim · Boots Pharmacy Thrush · Candiden · Canesten · Canesten AF Dual Action · Canesten Antifungal · Canesten Athlete's Foot · Canesten Dermatological · Clotrimazole · Fungederm · Galpharm Athletes Foot Cream · Lloydspharmacy Antifungal · Lloydspharmacy Athletes Foot · Lloydspharmacy Thrush Femme 
Canesten 
Canesten · Cloderm 
Canesten · Clotrimazolum · Fungotac · Imazol · Imazol plus 
Canestene Intim · Fungizid 
Canesten 
Canesderm · Canesten 
Canesten · Clotrimazolum · Klotrimazol 
Canesten
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