Terbinafine (ATC code: D01A E15) for topical application is classified as Probably not porphyrinogenic because of minimal systemic exposure.
For more details of the metabolism of terbinafine please refer to the monograph of terbinafine for systemic use (ATC code: D01B A02).
Hepatic exposure
Negligible
Metabolism and pharmacokinetics
Less than 5% of the dose is absorbed after topical application and systemic effect is therefore very limited (SPC).
IPNet drug reports
Uneventful use reported in 6 patients with acute porphyria.
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References
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Citation details
PMID
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Summary of Product Characteristics
1.
Norwegian medicines agency. Summary of Product Characteristics (SPC). terbinafin.