Monograph
D07AA02 - Hydrocortisone |
Propably not porphyrinogenic |
PNP |
Rationale
Probably only insignificant absorption. Ligand to PXR. Substrate for CYPs 3A4, 3A7, 11 B2. Inducer and inhibitor (!) of CYP 3A4. Several references stating non-porphyrinogenicity.
Chemical description
Mild glucocorticoid 0.1 % ointment used in dermatology. Systemic exposure on application on large areas of the body. Glucocorticoid: South African list: use. Kalman, Bonkovsky: believed to be safe. The Merck Manual: use. Moore MR, Hift RJ: Drugs in acute porphyria. Cell Mol Biol 43:89, 1997: safe. Tschudy DP, Lamon JM: Porphyrin metabolism and the Porphyrias in Bondy BK, Rosenberg LE (eds): Duncan’s Diseases of Metabolism, Philadelphia, WB Saunders 1980, p 939: safe.
IPNet drug reports
Uneventful use reported in 8 patients with acute porphyria.
Similar drugs
Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
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Hydrocortison · Hydrocortison-vaselinecrème 
Cremicort · Hydrocortisone · Pannocort 
Calmiox · Dermosa Hidrocortisona · Hidrocisdin · Lactisona 
Hidrocortizon 
Bites Stings · Boots Bite and Sting Relief Hydrocortisone · Derma Hydrocortisone · Dermacort hydrocortisone · Dioderm · Efcortelan · Exe-Cort Hydrocortisone · Hc45 Hydrocortisone · Hydrocortisone · Lanacort · Mildison Lipocream · Skincalm Hydrocortisone · Zenoxone 
Hydrokortison · Mildison 
Hydrokortison · Mildison 
Dermocort · Hydrocort · Hydrocortisonum · Hydrokortyzon Allefin · Maxicortan 
Cortisedermyl · Cremicort · Pannocort · Soventol · Soventol Hydrocortisonacetat 
Hydrokortison · Mildison 
Hydrocortison · Hydrocortisone 
Hydrocortison
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