Monograph
D07AB02 - Hydrocortisone Butyrate |
Propably not porphyrinogenic |
PNP |
Rationale
Probably only insignificant absorption. Ligand to PXR. Substrate for CYPs 3A4, 3A7, 11 B2. Inducer and inhibitor (!) of CYP 3A4. Several references stating non-porphyrinogenicity of glucocorticoids.
Chemical description
Moderately strong glucocorticoid ointment 0,1 % used in dermatology. Risk for some systemic exposure in application on large areas of the body. Glucocorticoid: South African list: use. Kalman, Bonkovsky: believed to be safe. The Merck Manual: use. Moore MR, Hift RJ: Drugs in acute porphyria. Cell Mol Biol 43:89, 1997: safe. Tschudy DP, Lamon JM: Porphyrin metabolism and the Porphyrias in Bondy BK, Rosenberg LE (eds): Duncan’s Diseases of Metabolism, Philadelphia, WB Saunders 1980, p 939: safe.
IPNet drug reports
Uneventful use reported in 5 patients with acute porphyria.
Similar drugs
Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Locoid 
Locoid · Locoid Lipocreme 
Locoid 
Hydrocortisone butyrate 0.1% ointment 10% in Hydrous ointment · Locoid · Locoid Crelo 
Locoid 
Alfason · Locoid 
Laticort · Locoid 
Locoid · Locoid Lipocreme 
Locoid 
Bucort · Locoid 
Laticort
© NAPOS 2025