Monograph
D07XA01 - Hydrocortisone |
Not porphyrinogenic |
NP |
Rationale
Hydrocortisone: Ligand to PXR. Substrate for CYPs 3A4, 3A7, 11 B2. Inducer and inhibitor of CYP 3A4. Several references stating non-porphyrinogenicity. urea: probably not absorbed.
Chemical description
Mild glucocorticoid in combination with the waterbinding agent carbamide. Glucocorticoid: South African list: use. Kalman, Bonkovsky: believed to be safe. The Merck Manual: use. Moore MR, Hift RJ: Drugs in acute porphyria. Cell Mol Biol 43:89, 1997: safe. Tschudy DP, Lamon JM: Porphyrin metabolism and the Porphyrias in Bondy BK, Rosenberg LE (eds): Duncan’s Diseases of Metabolism, Philadelphia, WB Saunders 1980, p 939: safe.
IPNet drug reports
Uneventful use reported in 3 patients with acute porphyria.
Similar drugs
Tradenames
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Pimafucort 
Detramax 
Izocon 
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