Monograph
D07XC01 - Betamethasone |
Not porphyrinogenic |
NP |
Rationale
The glucocorticoid and ASA components are stated in several references not to be porphyrinogenic. Probably only insignificant systemic exposure.
Chemical description
Strong glucocorticoid 0.5 mg/g in combination with acetylsalicylic acid. Ointment used in steroide sensitive dermatoses. Glucocorticoid : South African list: use. Kalman, Bonkovsky: believed to be safe. The Merck Manual: safe. Tschudy DP, Lamon JM: Porphyrin metabolism and the Porphyrias in Bondy BK, Rosenberg LE (eds): Duncan’s Diseases of Metabolism, Philadelphia, WB Saunders 1980, p 939: safe. Moore MR, Hift RJ: Drugs in acute porphyria. Cell Mol Biol 43:89, 1997: safe. Acetylsalicylic acid: South African list: safe. Kalman, Bonkovsky: safe. Michael Moore’s list: safe. The Merck Manual: safe . Eales L: Porphyria and the dangerous lifethreatening drugs, S Afr Med 56:914, 1979: safe.
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
Similar drugs
Tradenames
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Diprosalic 
Diprosalic · Lotriderm 
Alergical · Syracerin 
Diprosalic · sal-Ekarzin 
Betamethasone / Coal tar · Betamethasone / Ichthammol · Betesil · Chelsea cream 
Betamethason / Salicylsyre · Diprosalic · Diprosalinova 
Diprosalic 
Bedicort salic · Belosalic · Diprosalic · Salbetan · Triderm 
Diprosalic · Lotriderm 
Diprosalic 
Diprosalic 
Belosalic · Diprosalic
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