Monograph

J01DD01 - Cefotaxime

Propably not porphyrinogenic

Rationale

Metabolised only to a limited extent. No data pointing to CYP-interaction. Two references consider the drug safe.

Chemical description

Parenteral betalactamase stable cephalosporin used (1 g x 2) in various infections. Excreted in unchanged form (50-60 %), and as desacetyl derivative 15-25 %, by the kidneys within 24 hours. No data pointing to CYP interactions, South African list: use with caution. French list: safe.

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Tradenames

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