Monograph

J01MA02 - Ciprofloxacin

Propably not porphyrinogenic

Rationale

Competitive CYP-inhibitor. Some clinical experience of tolerance. Conflicting references.

Chemical description

Quinolone antibiotic. About 50% of the dose is excreted in unchanged form by the kidneys. Four metabolites are observed. Competetive inhibitor of several CYPs, possibly also at the transcrptional level. Some interference with fluorimetric determination of urinary porphyrins, reported. South African list: use with extreme caution only. French list: use. Australian list: safe. Thunell, patient enquiry: used without ill effects (n=1). Andersson: Used in some patients and well tolerated. See also: Schoenfelt and Mamet. Interference of ofloxacin with determination of urinary porphyrins. Clin Chem 1994, 40; 417-19.

IPNet drug reports

Uneventful use reported in 32 patients with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes J01M / J01MA or go back.

Tradenames

This list comprises raw data collected from different countries. In some cases, a more comprehensive list of available drug packages is included. Consequently, very similar terms may therefore appear multiple times. Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.

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Show more details and information about the listed tradenames

Ciprinol · Ciprofloxacin · Ciprofloxacine · Ciproxin · Ciproxine

Ciprofloxacin · Ciprofloxacine · Ciproxine

Araxacina · Baycip · Cetraxal · Ciprofloxacino · Ciprofloxacino Anages · Ciprofloxacino Korhispana · Doriman

Basemar · Battizer · Bosix · Chinocid · Ciperus · Ciprofloxacina · Ciproxin · Cuspis · Eoxin · Flontalexin · Generflon · Gerbat · Ibixacin · Kinox · Macar · Prociflor · Samper · Ullax