Monograph
J01MA02 - Ciprofloxacin |
Propably not porphyrinogenic |
PNP |
Rationale
Competitive CYP-inhibitor. Some clinical experience of tolerance. Conflicting references.
Chemical description
Quinolone antibiotic. About 50% of the dose is excreted in unchanged form by the kidneys. Four metabolites are observed. Competetive inhibitor of several CYPs, possibly also at the transcrptional level. Some interference with fluorimetric determination of urinary porphyrins, reported. South African list: use with extreme caution only. French list: use. Australian list: safe. Thunell, patient enquiry: used without ill effects (n=1). Andersson: Used in some patients and well tolerated. See also: Schoenfelt and Mamet. Interference of ofloxacin with determination of urinary porphyrins. Clin Chem 1994, 40; 417-19.
IPNet drug reports
Uneventful use reported in 32 patients with acute porphyria.
Similar drugs
Tradenames and packages
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Netherlands
Ciprinol · Ciprinol 250 mg, filmomhulde tabletten · Ciprinol 500 mg, filmomhulde tabletten · Ciprinol 750 mg, filmomhulde tabletten · Ciprofloxacin · Ciprofloxacin-hameln 2 mg/ml, oplossing voor infusie · Ciprofloxacine · Ciprofloxacine 250 mg, filmomhulde tabletten · Ciprofloxacine 500 mg, filmomhulde tabletten · Ciprofloxacine 750 mg, filmomhulde tabletten · Ciprofloxacine Accord 250 mg filmomhulde tabletten · Ciprofloxacine Accord 500 mg filmomhulde tabletten · Ciprofloxacine Accord 750 mg filmomhulde tabletten · Ciprofloxacine Altan 2 mg/ml oplossing voor infusie · Ciprofloxacine Aurobindo 250 mg filmomhulde tabletten · Ciprofloxacine Aurobindo 500 mg filmomhulde tabletten · Ciprofloxacine Aurobindo 750 mg filmomhulde tabletten · Ciprofloxacine CF 500 mg, filmomhulde tabletten · Ciprofloxacine Hikma 2 mg/ml, oplossing voor infusie · Ciprofloxacine Kabi 100 mg/50 ml, oplossing voor infusie 2 mg/ml · Ciprofloxacine Kabi 200 mg/100 ml, oplossing voor infusie 2 mg/ml · Ciprofloxacine Kabi 400 mg/200 ml, oplossing voor infusie 2 mg/ml · Ciprofloxacine Sandoz 100 mg, filmomhulde tabletten · Ciprofloxacine Sandoz 250 mg, filmomhulde tabletten · Ciprofloxacine Sandoz 500 mg, filmomhulde tabletten · Ciprofloxacine Sandoz 750 mg, filmomhulde tabletten · Ciprofloxacine Viatris 250 mg, filmomhulde tabletten · Ciprofloxacine Viatris 500 mg, filmomhulde tabletten · Ciproxin · Ciproxin 100 mg/ml, granulaat en oplosmiddel voor orale suspensie · Ciproxin 50 mg/ml, granulaat en oplosmiddel voor orale suspenie · Ciproxin 50 mg/ml, granulaat en oplosmiddel voor orale suspensie · Ciproxine · Ciproxine 100 mg/ml, granulaat en oplosmiddel voor orale suspensie · Ciproxine 50 mg/ml, granulaat en oplosmiddel voor orale suspensieBelgium
Ciprofloxacin · Ciprofloxacin Altan 2 mg/ml sol. perf. i.v. · Ciprofloxacine · Ciprofloxacine AB 250 mg compr. pellic. · Ciprofloxacine AB 500 mg compr. pellic. · Ciprofloxacine AB 750 mg compr. pellic. · Ciprofloxacine EG 250 mg compr. pellic. · Ciprofloxacine EG 500 mg (PI Pharma) compr. pellic. · Ciprofloxacine EG 500 mg compr. pellic. · Ciprofloxacine EG 750 mg compr. pellic. · Ciprofloxacine Fresenius Kabi 200 mg/100 ml sol. perf. i.v. · Ciprofloxacine Fresenius Kabi 400 mg/200 ml sol. perf. i.v. · Ciprofloxacine Sandoz 250 mg compr. pellic. · Ciprofloxacine Sandoz 500 mg (Orifarm) compr. pellic. · Ciprofloxacine Sandoz 500 mg (PI Pharma) compr. pellic. · Ciprofloxacine Sandoz 500 mg compr. pellic. · Ciprofloxacine Sandoz 750 mg compr. pellic. · Ciprofloxacine Teva 250 mg compr. pellic. · Ciprofloxacine Teva 500 mg compr. pellic. · Ciprofloxacine Teva 750 mg compr. pellic. · Ciprofloxacine Viatris 200 mg/100 ml sol. perf. i.v. · Ciprofloxacine Viatris 250 mg compr. pellic. · Ciprofloxacine Viatris 400 mg/200 ml sol. perf. i.v. · Ciprofloxacine Viatris 500 mg compr. pellic. · Ciproxine · Ciproxine 200 mg/100 ml sol. perf. i.v. · Ciproxine 50 mg/ml susp. buv. (gran. + solv.) · Ciproxine 500 mg compr. pellic.United Kingdom
Ciprofloxacin · Ciprofloxacin 100mg tablets · Ciprofloxacin 100mg/50ml solution for infusion bottles · Ciprofloxacin 100mg/50ml solution for infusion vials · Ciprofloxacin 100mg/5ml oral suspension · Ciprofloxacin 125mg/5ml oral suspension · Ciprofloxacin 150mg/5ml oral suspension · Ciprofloxacin 165mg/5ml oral suspension · Ciprofloxacin 170mg/5ml oral suspension · Ciprofloxacin 175mg/5ml oral suspension · Ciprofloxacin 200mg/100ml infusion bags · Ciprofloxacin 200mg/100ml solution for infusion bottles · Ciprofloxacin 200mg/100ml solution for infusion vials · Ciprofloxacin 20mg/5ml oral suspension · Ciprofloxacin 250mg tablets · Ciprofloxacin 250mg/5ml oral suspension · Ciprofloxacin 375mg/5ml oral suspension · Ciprofloxacin 400mg/200ml infusion bags · Ciprofloxacin 400mg/200ml solution for infusion bottles · Ciprofloxacin 400mg/200ml solution for infusion vials · Ciprofloxacin 40mg/5ml oral suspension · Ciprofloxacin 45mg/5ml oral suspension · Ciprofloxacin 500mg tablets · Ciprofloxacin 500mg/5ml oral suspension · Ciprofloxacin 50mg/5ml oral suspension · Ciprofloxacin 60mg/5ml oral suspension · Ciprofloxacin 750mg tablets · Ciprofloxacin 75mg/5ml oral suspension · Ciprofloxacin 80mg/5ml oral suspension · Ciproxin · Ciproxin 100mg tablets · Ciproxin 100mg/50ml solution for infusion bottles · Ciproxin 200mg/100ml solution for infusion bottles · Ciproxin 250mg tablets · Ciproxin 250mg/5ml oral suspension · Ciproxin 400mg/200ml solution for infusion bottles · Ciproxin 500mg tablets · Ciproxin 750mg tablets · Ciproxin I.V. Flexibag · Ciproxin I.V. Flexibag 200mg/100ml infusion · Ciproxin I.V. Flexibag 400mg/200ml infusionDenmark
Cifin · Ciprofloxacin · Ciprofloxacin "Actavis" · Ciprofloxacin "Fresenius Kabi" · Ciprofloxacin "HEXAL" · Ciprofloxacin "Krka" · Ciprofloxacin "Navamedic" · Ciprofloxacin "Orion" · Ciprofloxacin "Pharmathen" · Ciprofloxacin "Teva"Norway
Ciprofloxacin Actavis · Ciprofloxacin Navamedic · CiproxinPoland
Ciphin 500 · Ciprinol · Ciprofloxacin Kabi 100 mg/50 ml roztwór do infuzji · Ciprofloxacin Kabi 200 mg/100 ml roztwór do infuzji · Ciprofloxacin Kabi 400 mg/200 ml roztwór do infuzji · Cipronex · Cipropol · Proxacin 1% · Proxacin 250 · Proxacin 500Luxembourg
CIPROFLOXACIN · CIPROFLOXACIN KABI-100MG/50ML · CIPROFLOXACIN-RATIOPHARM-250 · CIPROFLOXACIN-RATIOPHARM-500 · CIPROFLOXACIN-RATIOPHARM-750 · CIPROFLOXACINE · CIPROFLOXACINE EG · CIPROFLOXACINE KABI-200MG/100ML · CIPROFLOXACINE KABI-400MG/200ML · Ciprofloxacine Viatris · CIPROXINEIceland
Ciprofloxacin · Ciprofloxacin Alvogen · Ciprofloxacin Navamedic · SíproxFinland
Ciprofloxacin Fresenius Kabi · Ciprofloxacin Krka · Ciprofloxacin Navamedic · Ciprofloxacin Orion · Ciprofloxacin Ratiopharm · CiproxinLatvia
Cifran · Ciprinol · Ciprofloxacin · Ciprofloxacin Aurobindo · Ciprofloxacin Norameda · Ciprofloxacin Olpha · Ciprofloxacin Sandoz · Ciprofloxacin Unifarma · CipronexSerbia
Ciprinol · Ciprinol® · Ciproave · Ciprocinal · Ciprocinal® · Ciprofloxacin · Ciprofloxacin Quatalia · Ciprofloxacin Remedica · Citeral · Citeral® · Marocen · Marocen®
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