hydantoin derivative. Associated with attacks. Several references warn against it.

Nitrofuran derivative used in urinary tract infections. Between 30% and 50% of the dose is excreted in urine in unchanged form. No further data on metabolism or CYP interaction. Australian list: unsafe/attacks. South African list: use with extreme caution only. Tschudy, Lamon: 1980 potentially unsafe. Moore MR, Hift RJ 1997: potentially unsafe. Martindale: Considerd unsafe, associated with attacks.

Uneventful use reported in 1 patient with acute porphyria.