Monograph
J05AF06 - Abacavir |
Propably not porphyrinogenic |
PNP |
Side effects
Common adverse reactions of abacavir that can be confused with an acute porphyric attack are nausea, vomiting and diarrhoea. These side effects may potentially be porphyrinogenic if leading to a decrease in carbohydrate intake.
Rationale
Abacavir is not a metabolized by CYP450 enzymes and is not an inducer or a mechanism-based inhibitor of CYP450 enzymes.
Chemical description
Nucleoside analogue
Therapeutic characteristics
Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI) indicated in the antiretroviral combination therapy for the treatment of HIV-1 infection in adults, adolescents and children. It is administered orally.
Metabolism and pharmacokinetics
Abacavir is mainly metabolized in the liver by alcohol dehydrogenase and by glucuronidation (SPC). Abacavir is not metabolized by CYP450 enzymes, and has been shown in vitro not to inhibit or induce CYP3A4, 2C9 and 2D6 (SPC). No drug-drug interactions with abacavir as perpetrator have been reported in the literature (interaktionsdatabasen.dk, Yuen 2008).
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | A review of the pharmacokinetics of abacavir.
Yuen GJ, Weller S, et al. Clin Pharmacokinet. 2008;47(6):351-71. |
|
| * | Drug interaction databases | |
| 2. | Interaktionsdatabasen. Abacavir.
|
|
| * | Summary of Product Characteristics | |
| 3. | The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). (Ziagen).
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Tradenames
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Abacavir · Ziagen 
Ziagen 
Abacavir · Ziagen 
Abacavir · Ziagen 
Abacavir · Ziagen 
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Abacavir · Ziagen 
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Abacavir · Ziagen 
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