Monograph
J07AE01 - Cholera, Inactivated, Whole Cell |
Propably not porphyrinogenic |
PNP |
Rationale
Based on the pharmacokinetics of the cholera, inactivated, whole cell vaccine, there are no conceivable porphyrinogenic effects.
Chemical description
Inactivated Vibrio Cholerae of different strains of serogroup O1 and the B subunit of the cholera toxin.
Therapeutic characteristics
Dukoral is indicated for active immunisation against disease caused by Vibrio cholerae serogroup O1 in adults and children from 2 years of age who will be visiting endemic/epidemic areas.
The vaccine is administered orally as two doses (three doses for children under 6), taken at least one week apart.
Metabolism and pharmacokinetics
The cholera vaccine is not metabolized by the cytochrome P450 system.
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Government bodies | |
| 1. | Norwegian Institute of Public Health. Vaksinasjonsveilederen. www.fhi.no (updated 13.10.2015).
|
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| * | Summary of Product Characteristics | |
| 2. | The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). Dukoral. (Last edition: March 2015).
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Tradenames
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Dukoral 
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Dukoral cholera vaccine 
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