Acute Porphyria Drugs

Acute Porphyria Drug Database

Monograph

L01BC05 - Gemcitabine
Not porphyrinogenic
NP
Rationale
Non-CYP metabolism. However, side effects such as nausea and vomiting may be potentially porphyrinogenic through reduction in caloric intake.
Chemical description
Gemcitabine hydrochloride is a synthetic pyrimidine nucleoside.
Therapeutic characteristics
Gemcitabine is an antimetabolite antineoplastic agent used in combinatiion with other cytostatatics in urine bladder cancer with metastases, advanced breast cancer, lung cancer or advanced ovarial cancer. Administered as an infusion. Common adverse reactions of gemcitabine that can be confused with an acute porphyric attack are nausea, vomiting, diarrhoea or obstipation. Side effects such as nausea and vomiting may be potentially porphyrinogenic through reduction in caloric intake.
Metabolism and pharmacokinetics
Gemcitabine is a pyrimidine antimetabolite that is rapidly metabolized by cytidine deaminase in the liver, kidneys and blood cells. About 91 - 98 per cent is converted to diphosphate dioxydifluorouridine, which is excreted in urine. Non-CYP metabolism, interactions with CYP-metabolism of other drugs not to be expected.
IPNet drug reports
No.

References

# Citation details PMID
*Drug reference publications
1. McEvoy GK, editor. Gemcitabine. The AHFS Drug Information 2008. Bethesda, MD: American Society of Health-System Pharmacists; 2009. Electronic version (04.12.09).
2. Sweetman SC, editor. Martindale: The complete drug reference. Gemcitabine. Pharmaceutical Press 2009.
*Summary of Product Characteristics
3. Norwegian medicines agency. Summary of Product Characteristics (SPC). Gemcitabin.
Similar drugs
Explore alternative drugs in similar therapeutic classes L01B / L01BC or go back.
Tradenames and packages
From some sources, we get a list of packages (United Kingdom, Ireland, Estonia). Other sources contain more or less "clean" versions of the trade name (Denmark, Finland, Iceland, Lithuania, Norway). What you see here is the raw data we get from each country, so there will appear to be duplicates. The bold names are the searchable terms. The gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.
Netherlands
Gemcitabine · Gemcitabine 1000 mg PCH, poeder voor oplossing voor infusie · Gemcitabine 1000 mg Pharmachemie B.V., poeder voor oplossing voor infusie · Gemcitabine 200 mg PCH, poeder voor oplossing voor infusie · Gemcitabine 200 mg Pharmachemie B.V., poeder voor oplossing voor infusie · Gemcitabine Accord 100 mg/ml Concentraat voor Oplossing voor Infusie · Gemcitabine Eugia 40 mg/ml, concentraat voor oplossing voor infusie · Gemcitabine Fresenius Kabi 38 mg/ml concentraat voor oplossing voor infusie · Gemcitabine Hikma 1 g, poeder voor oplossing voor infusie · Gemcitabine Hikma 200 mg, poeder voor oplossing voor infusie · Gemcitabine Hikma 38 mg/ml concentraat voor oplossing voor infusie · Gemcitabine Koanaa 1000 mg poeder voor oplossing voor infusie · Gemcitabine Koanaa 200 mg poeder voor oplossing voor infusie · Gemcitabine ratiopharm 40 mg/ml, concentraat voor oplossing voor infusie · Gemcitabine Sandoz 40 mg/ml, concentraat voor oplossing voor infusie · Gemcitabine SUN 1000 mg poeder voor oplossing voor infusie · Gemcitabine SUN 1200 mg oplossing voor infusie · Gemcitabine SUN 1300 mg oplossing voor infusie · Gemcitabine SUN 1400 mg oplossing voor infusie · Gemcitabine SUN 1500 mg oplossing voor infusie · Gemcitabine SUN 1600 mg oplossing voor infusie · Gemcitabine SUN 1700 mg oplossing voor infusie · Gemcitabine SUN 1800 mg oplossing voor infusie · Gemcitabine SUN 2000 mg oplossing voor infusie · Gemcitabine SUN 2200 mg oplossing voor infusie
Belgium
Gemcitabin · Gemcitabin Sandoz 40 mg/ml sol. perf. (à diluer) i.v. flac. · Gemcitabine · Gemcitabine Accord Healthcare 100 mg/ml sol. perf. (à diluer) i.v. flac. · Gemcitabine EG 38 mg/ml sol. perf. (à diluer) i.v. flac. · Gemcitabine Eugia 40 mg/ml sol. perf. (à diluer) i.v. flac. · Gemcitabine Fresenius Kabi 38 mg/ml sol. perf. (à diluer) i.v. flac. · Gemcitabine Fresenius Kabi 38 mg/ml sol. perf. (pdr.) i.v. flac. · Gemcitabine Hikma 38 mg/ml sol. perf. (à diluer) i.v. flac. · Gemcitabine Hospira 38 mg/ml sol. perf. (à diluer) i.v. flac.
United Kingdom
Gemcitabine · Gemcitabine 1.2g/120ml infusion bags · Gemcitabine 1.3g/130ml infusion bags · Gemcitabine 1.4g/140ml infusion bags · Gemcitabine 1.5g powder for solution for infusion vials · Gemcitabine 1.5g/150ml infusion bags · Gemcitabine 1.6g/160ml infusion bags · Gemcitabine 1.8g/180ml infusion bags · Gemcitabine 1026mg/250ml in Sodium chloride 0.9% infusion bags · Gemcitabine 1140mg/250ml in Sodium chloride 0.9% infusion bags · Gemcitabine 1300mg/250ml in Sodium chloride 0.9% infusion bags · Gemcitabine 1368mg/250ml in Sodium chloride 0.9% infusion bags · Gemcitabine 1400mg/250ml in Sodium chloride 0.9% infusion bags · Gemcitabine 1500mg/250ml in Sodium chloride 0.9% infusion bags · Gemcitabine 1520mg/250ml in Sodium chloride 0.9% infusion bags · Gemcitabine 1710mg/250ml in Sodium chloride 0.9% infusion bags · Gemcitabine 1900mg/250ml in Sodium chloride 0.9% infusion bags · Gemcitabine 1g powder for solution for infusion vials · Gemcitabine 1g/10ml concentrate for solution for infusion vials · Gemcitabine 1g/25ml concentrate for solution for infusion vials · Gemcitabine 1g/26.3ml concentrate for solution for infusion vials · Gemcitabine 2.2g/220ml infusion bags · Gemcitabine 200mg powder for solution for infusion vials · Gemcitabine 200mg/2ml concentrate for solution for infusion vials · Gemcitabine 200mg/5.26ml concentrate for solution for infusion vials · Gemcitabine 200mg/5.3ml concentrate for solution for infusion vials · Gemcitabine 200mg/5ml concentrate for solution for infusion vials · Gemcitabine 2128mg/250ml in Sodium chloride 0.9% infusion bags · Gemcitabine 2394mg/250ml in Sodium chloride 0.9% infusion bags · Gemcitabine 2400mg/250ml in Sodium chloride 0.9% infusion bags · Gemcitabine 2g powder for solution for infusion vials · Gemcitabine 2g/200ml infusion bags · Gemcitabine 2g/20ml concentrate for solution for infusion vials · Gemcitabine 2g/50ml concentrate for solution for infusion vials · Gemcitabine 2g/52.6ml concentrate for solution for infusion vials · Gemcitabine 1100mg/250ml in Sodium chloride 0.9% infusion bags · Gemcitabine 1254mg/250ml in Sodium chloride 0.9% infusion bags · Gemzar · Gemzar 1g powder for solution for infusion vials · Gemzar 200mg powder for solution for infusion vials
Denmark
Gemcitabin · Gemcitabin "Accord" · Gemcitabin "Sandoz" · Gemcitabin "SUN" · Gemkabi · Gemstada
Norway
Gemcitabin SUN · Gemcitabine Accord · Gemkabi
Poland
Gemcit · Gemcitabine Accord · Gemcitabine Kabi · Gemcitabine SUN · Gemcitabinum Accord · Gemsol
Luxembourg
Gemcitabine · Gemcitabine AB · GEMCITABINE EG · Gemcitabine Fresenius Kabi · GEMCITABINE HOSPIRA
Iceland
Gemcitabine · Gemcitabine WH · Gemkabi · Gitrabin
Finland
Gemcitabin Sandoz · Gemcitabin Sun · Gemcitabine Accord · Gemkabi
Latvia
Gemcit · Gemcitabine · Gemcitabine Accord · Gemcitabine Kabi · Gemsol
Serbia
Gemcitabin · Gemcitabin Ebewe® · Gemcitabin Kabi · Gemcitabine · Gemcitabine Accord · Gemcitabine Corapharm · Gemnil
 
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