Enzyme. Side effects such as nausea and vomiting may be potentially porphyrinogenic through reduction in caloric intake.

Asparaginase is an enzyme derived from Escherichia coli, that converts L-aspargine to aspartic acid and ammonia.

Asparaginase is an antineoplastic agent used for induction of remission in acute lymphattic leucemia. It is administered as an intravenous administration. Common adverse reactions of asparaginase that can be confused with an acute porphyric attack are nausea, vomiting, depression, confusion and irritability. Side effects such as nausea and vomiting may be potentially porphyrinogenic through reduction in caloric intake.

Not relevant.

Uneventful use reported in one 16-year old female patient with PV (Samuels, 1984).