Monograph
A01AB22 - Doxycycline |
Propably not porphyrinogenic |
PNP |
Rationale
Potent inhibitor of CYP3A4; MI-complex formation? Conflicting references. Several Swedish observations of non-porphyrinogenicity. Probably insignificant hepatic load in local dental use.
Chemical description
Tetracycline broad spectrum antibiotic with alkylamino group used in local treatment of tooth-pocket infections. Mainly unmetabolized but CYPs appear to be involved to some extent since CYP-inducing drugs result in an increase in its metabolism. Inhibitor of CYP 3A4 (MI-complex?).The concentration of the antibiotic in blood does not exceed 1 ug/ml. EPI-list: unsafe South African list: avoid Australian list: unsafe French list: safe Tschudy, Lamon 1980: safe (tetracycline) Thunell: A few observations of tolerance. Andersson: Several observations of tolerance. Peters: "Rather P?" See: Smith JR et al: Clamydial infection... (PMID 2759614): safe
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