Monograph
A06AD15 - Macrogol |
Not porphyrinogenic |
NP |
Rationale
Macrogols are not absorbed from the gastrointestinal tract.
Chemical description
Mixtures of long, linear polymers.
Therapeutic characteristics
Macrogols are used as osmotic laxatives. A solution of macrogol 3350 (or 4000) is used for the treatment of chronic constipation in a usual oral dose of 125 mL up to three times daily. Common adverse reactions of macrogols that can be confused with an acute porphyric attack are gastrointestinal discomfort, bloating, and nausea.
Metabolism and pharmacokinetics
Not absorbed from the garstrointerstinal tract, eliminated in feces.
IPNet drug reports
Uneventful use reported in 2 patients with acute porphyria.
References
| # | Citation details | PMID |
|---|---|---|
| * | Drug reference publications | |
| 1. | Sweetman SC, editor. Martindale: The complete drug reference. Macrogols. Pharmaceutical Press 2009.
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