Acute Porphyria Drug Database

Monograph

M01AE51 - Ibuprofen, Combinations
Propably not porphyrinogenic
PNP

Rationale
ibuprofen: Propionic acid derivative metabolised mainly by CYP 2C9. No clinical data pointing to CYP-inducing effects. Did not induce ALAS1 in rat. codeine: Opioid, substrate for CYPs 2D6 and 3A4 3A7 (minor reactions) No clinical data pointing to CYP-inducing effects. Several references consider it safe.
Chemical description
Tabl 200-800 mg/d. ibuprofen Analgetic and antiflogistic propionic acid derivative, effective through its cyclooxygenas inhibiting effect. Hydroxylated by CYP2C9 (major enzyme) and 2C8. Inhibitor of CYP 2C9. Excreted as two metabolites. No data pointing to CYP-induction codeine Opoid phenantrene derivative with analgesic and antitussive properties, metabolized by CYP 2D6 and to a minor extent by 3A4 and 3A7. ibuprofen South African list: use. French list: interdit. codeine South African list: use. French list: authorized. Anderson KE: Effects of antihypertensive drugs on hepatic heme biosynthesis....Boichem Biophys Acta 543:313, 1978 : safe. Moore MR, Hift RJ: Drugs in the acute porphyrias - Toxicogentic diseases Cell Mol Biol 43:89, 1997: safe.
Similar drugs
Explore alternative drugs in similar therapeutic classes M01A / M01AE or go back.
Tradenames
This list comprises raw data collected from different countries. In some cases, a more comprehensive list of available drug packages is included. Consequently, very similar terms may therefore appear multiple times. Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.


Brufen Plus Paracetamol Dolalgial Ibuprofeno / Cafeina · Grippostad Ibuprofeno Forte · Ilvisinus Analgex · Biofen · Biofen Plus · Combifexin · Ibuprom · Ibuvalen · Nurofen · Nurofen Plus · Paduden · Parasinus · Synocam Boots Cold and Flu Relief with Ibuprofen · Deep Relief · Ibuprofen / Levomenthol · Lemsip Cold and Flu Sinus 12 Hr Ibuprofen + Pseudoephedrine · Lemsip Flu 12 Hr Ibuprofen + Pseudoephedrine · Lemsip Ibuprofen · Lemsip Max All Night Cold & Flu · Nurofen · Nurofen Cold & Flu Relief · Nurofen Cold and Flu · Nurofen Sinus & Blocked Nose · Orbifen Cold & Flu · Sudafed · Sudafed Sinus Pressure & Pain Acatar · APAP intense · Apselan Plus · Gexiro · ibu-spa · Ibum · Ibum Grip · Ibunoven · Ibuprofen / Paracetamol · Ibuprom · Inflanor Plus · Kidofen · Metafen · Modafen Grip · Nurofen · Nurofen Plus · Nurofen Ultima · Zatoki · Zatotabs Brufen Plus Paracetamol Parapró Burana-C · Ibumax-C Tonufen Ibumax · Metafex
 
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