Monograph
N01BA04 - Chloroprocaine |
Propably not porphyrinogenic |
PNP |
Rationale
Chloroprocaine does not induce or inhibit any CYP enzymes, and no pharmacokinetic porphyrinogenic effects are suspected.
Chemical description
Chloroprocaine is an ester anesthetic, and is a derivative of benzoic acid.
Therapeutic characteristics
Chloroprocaine is indicated for the production of local anesthesia by infiltration, peripheral and central nerve block, including lumbar and caudal epidural blocks (drugs.com, UpToDate)
Choroprocain has a lower potential for systemic toxicity than other local anaesthetics, which allows a higher dosing. It has a fast onset of action, and a due to low protein binding it has a short duration (Columb 2010).
Metabolism and pharmacokinetics
Chloroprocaine is rapidly hydrolyzed by plasma enzymes to 2-chloro-4-aminobenzoic acid and beta-diethylaminoethanol. (Micromedex, Uptodate) Chloroprocaine is not metabolized by CYP enzymes, and is not suspected to interact with the CYP metabolism of other drugs (Lexi-Interact, Micromedex)
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Local anaesthetic agents. Anaesth Intensive Care. March 2010, Volume 11, Issue 3, Pages 113-117
Columb MO, Ramsaran R. |
|
| * | Drug reference publications | |
| 2. | [Chloroprocaine]. In: UpToDate. ((Accessed: 16. February 2018).
|
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| 3. | Chloroprocaine: Uses, Dosage & Side Effects. (Accessed: 16. February 2018).
|
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| 4. | Micromedex® 2.0 (online). Chloroprocaine (Drugdex System). (updated: 26.01.2018).
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| * | Drug interaction databases | |
| 5. | Lexi-Interact, via UpToDate.
|
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| 6. | Micromedex® 2.0 (online). Drug Interactions). (16.02.2018).
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