Monograph

N01BA04 - Chloroprocaine

Propably not porphyrinogenic

Rationale

Chloroprocaine does not induce or inhibit any CYP enzymes, and no pharmacokinetic porphyrinogenic effects are suspected.

Chemical description

Chloroprocaine is an ester anesthetic, and is a derivative of benzoic acid.

Therapeutic characteristics

Chloroprocaine is indicated for the production of local anesthesia by infiltration, peripheral and central nerve block, including lumbar and caudal epidural blocks (drugs.com, UpToDate) Choroprocain has a lower potential for systemic toxicity than other local anaesthetics, which allows a higher dosing. It has a fast onset of action, and a due to low protein binding it has a short duration (Columb 2010).

Metabolism and pharmacokinetics

Chloroprocaine is rapidly hydrolyzed by plasma enzymes to 2-chloro-4-aminobenzoic acid and beta-diethylaminoethanol. (Micromedex, Uptodate) Chloroprocaine is not metabolized by CYP enzymes, and is not suspected to interact with the CYP metabolism of other drugs (Lexi-Interact, Micromedex)

References

#	Citation details	PMID
*	Scientific articles
1.	Local anaesthetic agents. Anaesth Intensive Care. March 2010, Volume 11, Issue 3, Pages 113-117 Columb MO, Ramsaran R.
*	Drug reference publications
2.	[Chloroprocaine]. In: UpToDate. ((Accessed: 16. February 2018).
3.	Chloroprocaine: Uses, Dosage & Side Effects. (Accessed: 16. February 2018).
4.	Micromedex® 2.0 (online). Chloroprocaine (Drugdex System). (updated: 26.01.2018).
*	Drug interaction databases
5.	Lexi-Interact, via UpToDate.
6.	Micromedex® 2.0 (online). Drug Interactions). (16.02.2018).

Citation details

PMID

Scientific articles

Local anaesthetic agents. Anaesth Intensive Care. March 2010, Volume 11, Issue 3, Pages 113-117

Columb MO, Ramsaran R.

Drug reference publications

[Chloroprocaine]. In: UpToDate. ((Accessed: 16. February 2018).

Chloroprocaine: Uses, Dosage & Side Effects. (Accessed: 16. February 2018).

Micromedex® 2.0 (online). Chloroprocaine (Drugdex System). (updated: 26.01.2018).

Drug interaction databases

Lexi-Interact, via UpToDate.

Micromedex® 2.0 (online). Drug Interactions). (16.02.2018).

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Tradenames and packages

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Netherlands