Monograph
N02AA01 - Morphine |
Not porphyrinogenic |
NP |
Rationale
Several references as well as significant clinical experience indicate non-porphyrinogenicity.
Chemical description
Opioid analgesic often used in acute porphyric crisis. After conjugation with glucuronic acid to morphine-3-glucuronide it is eliminated by the kidneys. MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use EPI-list: safe South African list: use French list: use Kalman, Bonkovsky: safe Anderson KE: Effects of antihypertensive drugs on hepatic heme biosynthesis, and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme pathway induction.Biochem Biophys Acta 543:313, 1978: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: probably safe.
IPNet drug reports
Uneventful use reported in 41 patients with acute porphyria.
Similar drugs
Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
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Diacetylmorfine · Molnex · Morfine · Morfinesulfaat · MS Contin · Oramorph · Sendolor 
Morphine · MS Contin · MS Direct · Oramorph 
Dolq · Maracex · Morfina · MST Continus · Oramorph · Sevredol 
Morphine · Morphinum · MST Continus · Sevredol 
Morfina · MS Contin · Oramorph · Twice 
Morfina · Sevredol · Vendal 
Kapanol · M-retard · Morphin · Morphine · Morphini · MST Continus · Oramorph · Sevre-Long · Sevredol 
Actimorph · Depodur · Filnarine SR · Morcap SR · Morphgesic SR · Morphine · Morphine 0.1% in Intrasite gel · Morphine 0.2% in Intrasite gel · Morphine hydrochloride · Morphine sulfate · MST Continus · mxl · Oramorph · Sendolor · Sevredol · Zomorph 
Contalgin · Depolan · Doltard · Malfin · Morfin · Morfinsulfat · Morphinsulfat · Oramorph · Sendolor 
Contalgin · Dolcontin · Malfin · Morfin · Morfine · Oramorph · Sevre-Long 
Doltard · Maracex · Morfina · Morphine · Morphini sulfas · MST Continus · Oramorph · Sevredol · Vendal 
Morphine · MS Contin · MS Direct · Oramorph · Sendolor 
Contalgin · Morfin · Morphine 
Molnex · Morphin · Oramorph · Sendolor 
Doltard · Maracex · Morphin · Morphine · Morphini sulfas · Vendal 
Morfina · Morphin · Vendal 
Doltard · Maracex · Morfin · MST Continus · mxl · Sevredol · Vendal 
Morfin · Oramorph 
Analgeticna morfinom · Doltard · Kapanol · M-eslon · Morfin · Morfinijev · Morphin · Morphini Sulfas · msi Mundipharma · MST Continus · Opijeva · Oramorph · Sevredol · Substitol