Monograph

N02AA03 - Hydromorphone

Propably not porphyrinogenic

Rationale

Opioid. References state non-porphyrinogenicity.

Chemical description

Opioid analgesic metabolized to a large extent and excreted in urine in conjugated form. Anderson KE: Effects of antihypertensive drugs on hepatic heme biosynthesis, and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme pathway induction.Biochem Biophys Acta 543:313, 1978: safe. Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: probably safe.

IPNet drug reports

Uneventful use reported in 1 patient with acute porphyria.

Similar drugs

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Tradenames

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