Monograph
N02AA05 - Oxycodone |
Propably not porphyrinogenic |
PNP |
Rationale
Oxycodone is a substrate of CYP3A4, but is not an inhibitor or an inducer of CYP3A4 or other major CYP enzymes.
Risk for gastrointestinal adverse events in the form of obstipation, nausea, vomiting, loss of appetite, abdominal pain, diarrhoea and dyspepsia motivates vigilance against insufficient intake of food, especially of carbohydrate.
Chemical description
Oxycodone is an opioid.
Therapeutic characteristics
Very common side effects that can be potentially porphyrinogenic through reduction in carbohydrate intake and that also can be confused with an acute porphyria attack are obstipation, nausea and vomiting. Other common side effects are loss of appetite, abdominal pain, diarrhoea and dyspepsia.
Metabolism and pharmacokinetics
Oxycodone is metabolised to noroxycodone and oxymorphone by CYP3A4 and CYP2D6 respectively. They are then metabolised to noroxymorphone and excreted.
Oxycodone is not an inhibitor or an inducer of CYP3A4 (Interaksjoner and Soderberg 2013) or other major CYP enzymes.
Personal communication
Andersson clinical observation (n=1): tolerated.
Published experience
Oxycodone is listed as unsafe for patients with acute porphyria (Moore 2000).
IPNet drug reports
Uneventful use reported in 2 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Moore AW 3rd, Coke JM. Acute porphyric disorders.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Sep;90(3):257-62. |
10982942 |
| 2. | Cytochrome p450-mediated changes in oxycodone pharmacokinetics/pharmacodynamics and their clinical implications.
Söderberg Löfdal KC, Andersson ML, Gustafsson LL. Drugs. 2013 May;73(6):533-43. |
23605691 |
| * | Drug interaction databases | |
| 3. | Interaksjoner. Oxycodone. Accessed : 14.08.2013
|
|
| * | Summary of Product Characteristics | |
| 4. | Norwegian medicines agency. Summary of Product Characteristics (SPC). Oksykodon.
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Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Oxycodon · Oxycodon-HCl · OxyContin · OxyNorm 
Oxycodon · Oxycodone · OxyNorm 
Oxicodona · Oxycontin · Oxynorm · Taioma 
Ossicodone · Oxicodone · Oxycontin 
Oxicodona · Oxidolor 
Abtard · Candox · Carexil · Dolocodon · Dolocodon PR · Ixyldone · Leveraxo · Longtec · Lynlor · Onexila · Oxeltra · Oxyact · Oxycodone · OxyContin · Oxylan · OxyNorm · OxyNorm liquid · Oxypro · Proladone · Reltebon · Renocontin · Shortec · Zomestine 
Codilek · Coxynon · Lindoxa · Oxycodone · Oxycodonhydrochlorid · OxyContin · Oxylan · OxyNorm · Reltebon 
Oksykodon · Oxycodone · OxyContin · OxyNorm · Reltebon 
Accordeon · Oxycodon · Oxycodone · OxyContin · Oxydolor · OxyNorm · Reltebon · Xancodal 
OxyNorm · Oxypro 
Oxikodon · Oxycodone · OxyContin · OxyNorm 
Oxanest · Oxycodone · Oxycontin · Oxycorion · Oxynorm · Oxyratio 
Oxycodone 
Codexy
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