Monograph

N03AX11 - Topiramate

Probably porphyrinogenic

Rationale

Substrate for 3A4. Ligand to PXR and light to moderately strong inducer of CYP 3A4.

Chemical description

Tabl; 200-1000 mg/d. Sulfamate substituted monosaccharide used for additional treatment in patients with partial or generalized epileptic attacks. Metabolized by CYP 3A. Nallani et al. Topiramate. An antiepileptic agent that activates pregane X receptror and induces cytochrome P450 3A4 enzyme. Drug metab Rev Abstr 8th Europ Meeeting, Dijonâ€¦.2003: Vol 35; Abs 159, p 80.

IPNet drug reports

Uneventful use reported in 1 patient with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes N03A / N03AX or go back.

Tradenames

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