Monograph
N03AX11 - Topiramate |
Probably porphyrinogenic |
PRP |
Rationale
Substrate for 3A4. Ligand to PXR and light to moderately strong inducer of CYP 3A4.
Chemical description
Tabl; 200-1000 mg/d. Sulfamate substituted monosaccharide used for additional treatment in patients with partial or generalized epileptic attacks. Metabolized by CYP 3A. Nallani et al. Topiramate. An antiepileptic agent that activates pregane X receptror and induces cytochrome P450 3A4 enzyme. Drug metab Rev Abstr 8th Europ Meeeting, Dijon….2003: Vol 35; Abs 159, p 80.
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
Similar drugs
Tradenames and packages
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Other sources contain more or less "clean" versions of the trade name (Denmark, Finland, Iceland, Lithuania, Norway).
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Netherlands
Belgium
United Kingdom
Denmark
Norway
Poland
Luxembourg
Iceland
Finland
Latvia
Serbia
