Monograph
N05AB02 - Fluphenazine |
Not porphyrinogenic |
NP |
Rationale
Substrate of CYP 2D6. Inhibitor of CYPs 2D6, 1A2, 2E1, 3A4. Several references state non-porphyrinogenicity (phenothiazines in general).
Chemical description
Low-dose phenothiazine neuroleptic used in manic and psychotic conditions Metabolized by CYP 2D6. No data indicating CYP-induction. MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use (phenothiazines). Australian list: safe EPI-list: safe South African list: use French list: use (fluphenazine) Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe
Similar drugs
Tradenames
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Modecate 
Fluphenazine · Fluphenazine decanoate · Modecate · Modecate Concentrate · Moditen 
Fluphenazine · Modecate 
Metoten · Moditen
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