Monograph
N05AB06 - Trifluoperazine |
Propably not porphyrinogenic |
PNP |
Rationale
Substrate and in some cases inhibitor of Cyp2D6. No basis for assumption of Cyp TDI properties. 40 reports of safe use indcates that the phenothiaze -N/-S heterocycle is devod of porphyrogenicity in a way not significantly influenced by side chain structures.
Chemical description
Phenothiazin derivatives with dimethylaminopropyl side chain or piperazine ring side chain. Generally administered as water-soluble salts.
Therapeutic characteristics
Neuroleptics, anxtiolytics
Antimuscarinic effects.
Confounding side effects: Tachycardia
Hepatic exposure
In some cases probably significant
Metabolism and pharmacokinetics
Generally metabolized by Cyp2D6, some being inhibitors of CypD6 without effects connected with significant Cyp TDI.
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
40 reports of safe use of drugs within these two groups of phenotiazines, none of porphyrogenicity
Similar drugs
Tradenames
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Modalina 
Stelazine · Stelazine Forte · Terrazine · Trifluoperazine
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