Monograph

N05AH02 - Clozapine

Propably not porphyrinogenic

Rationale

Substrate of CYP 1A2, 2C19, 2C8, 2C9, 2D6, 3A4 (major enzyme at higher concentrations), 2C19, 2E1. Inhibitor of CYP 3A4 (low potency), 2D6, 2C19, 2C9. References consider it safe for use. Observed not to be porphyrinogenic in long-term treatment of one patient (Sweden).

Chemical description

High-dose neuroleptic (benzodiazepine derivative) used in therapy resistent schizophrenia. Extensively metabolized via CYPs. South African list: use with care French list: use. See Holoryd S et al. Psychotropic drugs in acuteâ€¦(one case) (PMID: 10511069). Thunell; clinical experience from prolonged treatment (n=1): no porphyric side effects.

Personal communication

Report on uneventful use: One report of uneventful use of clozapine for 2-3 years in female AIP patient with known mutation. Porphyrin excretion low/normal during use. From Dr Salamanca, Madrid.

IPNet drug reports

Uneventful use reported in 1 patient with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes N05A / N05AH or go back.

Tradenames and packages

From some sources, we get a list of packages (United Kingdom, Ireland, Estonia). Other sources contain more or less "clean" versions of the trade name (Denmark, Finland, Iceland, Lithuania, Norway). What you see here is the raw data we get from each country, so there will appear to be duplicates. The bold names are the searchable terms. The gray names that follow are all mapped to the bolded term.

Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.

Netherlands

Ayupine · Ayupine 100 mg, orodispergeerbare tabletten · Ayupine 12,5 mg, orodispergeerbare tabletten · Ayupine 200 mg, orodispergeerbare tabletten · Ayupine 25 mg, orodispergeerbare tabletten · Ayupine 50 mg, orodispergeerbare tabletten · Clozapine · Clozapine 100 mg Teva, tabletten · Clozapine 100 mg, tabletten · Clozapine 25 mg Teva, tabletten · Clozapine 25 mg, tabletten · Clozapine 50 mg, tabletten · Clozapine Accord 100 mg, tabletten · Clozapine Accord 200 mg, tabletten · Clozapine Accord 25 mg, tabletten · Clozapine Accord 50 mg, tabletten · Clozapine Aristo 100 mg, tabletten · Clozapine Aristo 200 mg, tabletten · Clozapine Aristo 25 mg, tabletten · Clozapine Aristo 50 mg, tabletten · Clozapine Auro 100 mg, tabletten · Clozapine Auro 200 mg, tabletten · Clozapine Auro 25 mg, tabletten · Clozapine CF 100 mg, tabletten · Clozapine CF 200 mg, tabletten · Clozapine CF 25 mg, tabletten · Clozapine Glenmark 100 mg tabletten · Clozapine Glenmark 200 mg tabletten · Clozapine Glenmark 25 mg tabletten · Clozapine Glenmark 50 mg tabletten · Clozapine Leyden Delta 100 mg, tabletten · Clozapine Leyden Delta 25 mg, tabletten · Clozapine Leyden Delta 50 mg, tabletten · Clozapine Mylan 100 mg, tabletten · Clozapine Mylan 25 mg, tabletten · Clozapine Sandoz 100, tabletten 100 mg · Clozapine Sandoz 200 mg, tabletten · Clozapine Sandoz 25, tabletten 25 mg · Clozapine Sandoz 50, tabletten 50 mg · Clozapine Viatris 100 mg, tabletten · Clozapine Viatris 25 mg, tabletten · Leponex · Leponex 100 mg tabletten · Leponex 25 mg tabletten · Zaponex · Zaponex 100 mg, orodispergeerbare tabletten · Zaponex 12,5 mg, orodispergeerbare tabletten · Zaponex 200 mg, orodispergeerbare tabletten · Zaponex 25 mg, orodispergeerbare tabletten · Zaponex 50 mg, orodispergeerbare tabletten

Belgium

Clozapine · Clozapine Sandoz 100 mg comp. · Clozapine Sandoz 25 mg comp. · Clozapine Sandoz 50 mg comp. · Leponex · Leponex 100 mg comp. · Leponex 200 mg comp. · Leponex 25 mg comp.

United Kingdom

Clozapine · Clozapine 100mg tablets · Clozapine 100mg/5ml oral solution · Clozapine 100mg/5ml oral suspension · Clozapine 125mg/5ml solution for injection ampoules · Clozapine 25mg tablets · Clozapine 50mg/ml oral suspension sugar free · Clozapine diluent oral solution · Clozaril · Clozaril 100mg tablets · Clozaril 25mg tablets · Denzapine · Denzapine 100mg tablets · Denzapine 200mg tablets · Denzapine 25mg tablets · Denzapine 50mg tablets · Denzapine 50mg/ml oral suspension · Zaponex · Zaponex 100mg orodispersible tablets · Zaponex 100mg tablets · Zaponex 12.5mg orodispersible tablets · Zaponex 200mg orodispersible tablets · Zaponex 25mg orodispersible tablets · Zaponex 25mg tablets · Zaponex 50mg orodispersible tablets

Denmark

Cloprinex · Clozapin · Clozapin "Accord" · Clozapin "Ebb Medical" · Clozapin "Epione Medicine" · Clozapin "Hexal" · Clozapin "Mashal" · Clozapin "Mylan" · Clozapin "Nordic Prime" · Clozapin Accord · Clozapin Hexal · Froidir · Leponex · Prizapin

Norway