Monograph

N05BA06 - Lorazepam

Propably not porphyrinogenic

Rationale

Directly conjugated with glucuronic acid. Several references consider it safe.

Chemical description

Benzodiazepine anxiolytic. Eliminated by direct conjugation with glucuronic acid. Conflicting experimental evidence of porphyrinogenicity (Martindale) MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use with care. EPI-list: safe South African list: use French list: use Australian list: safe (conflicting evidence) See Holoryd S et al. Psychotropic drugs in acute... (PMID10511069): safe (n=1). Kauppinen and Mustajoki. Prognosis of acute porphyria... Medicine 1992; 71: 1-13: tolerated (N=1). Used in porphyria ward (Sweden)

IPNet drug reports

Uneventful use reported in 12 patients with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes N05B / N05BA or go back.

Tradenames

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