Monograph
N05BA06 - Lorazepam |
Propably not porphyrinogenic |
PNP |
Rationale
Directly conjugated with glucuronic acid. Several references consider it safe.
Chemical description
Benzodiazepine anxiolytic. Eliminated by direct conjugation with glucuronic acid. Conflicting experimental evidence of porphyrinogenicity (Martindale) MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use with care. EPI-list: safe South African list: use French list: use Australian list: safe (conflicting evidence) See Holoryd S et al. Psychotropic drugs in acute... (PMID10511069): safe (n=1). Kauppinen and Mustajoki. Prognosis of acute porphyria... Medicine 1992; 71: 1-13: tolerated (N=1). Used in porphyria ward (Sweden)
IPNet drug reports
Uneventful use reported in 12 patients with acute porphyria.
Similar drugs
Tradenames and packages
From some sources, we get a list of packages (United Kingdom, Ireland, Estonia).
Other sources contain more or less "clean" versions of the trade name (Denmark, Finland, Iceland, Lithuania, Norway).
What you see here is the raw data we get from each country, so there will appear to be duplicates. The bold names
are the searchable terms. The gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Netherlands
Belgium
United Kingdom
Denmark
Norway
Poland
Luxembourg
Finland
Latvia
Serbia
