Monograph
N05CM06 - Propiomazine |
Not porphyrinogenic |
NP |
Rationale
phenothiazine, extensively metabolised in the liver. Several references consider it safe for use. Clinical experience and results of patient inquiry point to non-porphyrinogenicity.
Chemical description
Hypnotic phenothiazine derivative, extensively metabolized in the liver. MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use (phenothiazines). Kalman, Bonkovsky: safe. Anderson KE: Effects of antihypertensive drugs on hepatic heme biosynthesis,..... Biochem Biophys Acta 543:313, 1978: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe. S.Thunell; patient inquiry: used without illeffects (n=5) Andersson:
IPNet drug reports
Uneventful use reported in 8 patients with acute porphyria.
Similar drugs
Tradenames
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Propavan
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