Monograph
A07EA01 - Prednisolone |
Propably not porphyrinogenic |
PNP |
Rationale
Partly absorbed. Substrate for CYP 3A4, 3A7 and 11B2. Selective inducer of CYP 3A4. Vast experience and several references indicate non-porphyrinogenicity of glucocorticoids.
Chemical description
Glucocorticoid used as clysma in proctitis and ulcerating colitis. About 40% absorbed. Metabolized mainly by CYP 11B2 and 3A4. Selective inducer of CYP 3A4. South African list: use. French list: authorized. Merck Index: safe Kahlman, Bonkowky: Believed to be safe. Tschudy DP, Lamon JM. Porphyria metabolism and the porphyrias, in Bondy PK, Rosenberg LE (eds.): Duncan’s diseases of metabolism. Philadelphia: safe.
IPNet drug reports
Uneventful use reported in 4 patients with acute porphyria.
Similar drugs
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