Monograph
N07AA51 - Neostigmine, Combinations |
Propably not porphyrinogenic |
PNP |
Rationale
Neostigmine: Probably not interfering with hepatic CYPs. References consider it safe. Glycopyrrone: Not metabolised. References consider it safe
Chemical description
A combination of an anticholinergic and a cholinesterase inhibitor used for reversal of non-depolarisation neuromuscular blockade Neostigmine: Cholinesterase inhibitor of short duration. No data pointing to CYP-interaction. Glucopyrrone: Quarternary ammonium compound with anticholinergic properties. Ionized at physiological pH. Rapidly excreted in unchanged form in urine. Neostigmine: MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use EPI-list: safe South African list: use Glycopyrrone: MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use EPI-list: safe
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