Monograph

N07BC01 - Buprenorphine

Not porphyrinogenic

Rationale

Opioid, substrate of CYP 3A4. Clinical experience (Sweden) of non-porphyrinogenicity. Four references consider it safe.

Chemical description

Partial opioid agonist/antagonist used in treatment of opioid dependence, metabolized by CYP 3A4 and glucuronidation. Inhibitor of CYP 3A4 and 2D6. Australian list: safe EPI-list: safe South African list: use French list: use

IPNet drug reports

Uneventful use reported in 1 patient with acute porphyria.

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Tradenames

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