Monograph
P02CX01 - Pyrvinium |
Not porphyrinogenic |
NP |
Rationale
Pyrvinium is not absorbed from the gastrointestinal tract and is therefore not porphyrinogenic.
Chemical description
Phenylpyrrol methylquinolone (administered as embonate)
Therapeutic characteristics
Pyrvinium is an anthelmintic with special effect against Enterobius vermicularis (pinworms).
Side effects that may occur include nausea, vomiting, abdominal pain, diarrhoea.
Hepatic exposure
Practically none.
Metabolism and pharmacokinetics
Pyrvinium is not significantly absorbed from the gastrointestinal tract (Smith 1976).
IPNet drug reports
Uneventful use reported in 3 patients with acute porphyria.
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Absorption of pyrvinium pamoate.
Smith TC, Kinkel AW et al. Clin Pharmacol Ther. 1976 Jun;19(6):802-6. |
|
| * | Summary of Product Characteristics | |
| 2. | Norwegian medicines agency. Summary of Product Characteristics (SPC). (Vanquin).
|
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