Monograph

R01AD05 - Budesonide

Not porphyrinogenic

Rationale

Probably insignificant systemic exposure. Several references stating non-porphyrinogenicity of glucocorticoids.

Chemical description

Glucocorticoide with strong antiinflammatory effect used in nasal spray in allergic and vasomotor rhinitis. The amount of budesonide in each dose is 50 - 100 Âµg. Systemic exposure 33%. Used in porphyria ward (Sweden). EPI-list: safe French list: authorized. South African list: use Kalman, Bonkowski: safe The Merck Manual: safe Tschudy DP, Lamon JM: Porphyrin metabolism and the porphyrias, in Bondy PK, Rosenberg LE (eds.): Duncan's Diseases of Metabolism. Philadelphia, WB Saunders, 1980, p939: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe

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