Monograph

R03AC12 - Salmeterol

Propably not porphyrinogenic

Rationale

Substrate for CYP 3A4. Probably insignificant metabolic load.

Chemical description

Adrenergic administered in asthma in inhalation aerosol, 50 Âµg/dose. Gives rise only to very low plasma concentrations. Metabolized in the liver (CYP 3A4) producing several metabolites.

IPNet drug reports

Uneventful use reported in 4 patients with acute porphyria.

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Tradenames

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